Humana; 1 edition (September 1, 2004) | 1588293327 | Pages: 436 | PDF | 8.06 MB
A panel of researchers and experts from leading universities and major pharmaceutical companies from all over the world
systematically describe cutting-edge experimental protocols for the
early in vitro evaluation of new chemical entities (NCE). These readily
reproducible assays measure such critical parameters as physicochemical
properties, adsorption, plasma binding,
metabolism, drug interactions, and toxicity. By uncovering early in the
discovery stage the defects that can eliminate candidate drugs from
preclinical and clinical development, these techniques can save millions
of dollars in time and effort. optimization drug discovery,
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